Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases

摘要: Many intervertebral disc diseases cause low back pain (LBP). Proinflammatory cytokines and matrix metalloproteinases (MMPs) participate in pathology. In this study, we examined levels of serum MMPs human subjects with diagnoses herniation (DH), spinal stenosis (SS), or degenerative disease (DDD) relative to control subjects. Comparison between DH those other (Other Dx, grouped from SS DDD) was performed elaborate a pathological mechanism based on circulating cytokine levels. Study participants were recruited spine neurosurgery practice (n = 80), management (n = 27), cohort (n = 26). Serum samples collected before treatment assayed by multiplex assays for interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ, tumor necrosis factor-α, MMP-1, MMP-3, MMP-9. Inflammatory degradative mediator compared LBP subjects, diagnosis groups, controlling effects sex, age, reported history osteoarthritis. Spearman’s correlation coefficient used examine relationships body mass index (BMI), symptom duration, smoking history. IL-6 significantly higher Participants due Other Dx had than controls. MMP-1 lower specifically DH, Positive correlations found BMI, age. positively correlated The findings the present clinical study are results first examination DDD provide evidence more extensive role diseases, where patients have These suggest that low-grade systemic inflammation, biochemical profiling may assist refining personalized diseases.