Immobilization of radionuclides on poly(lactide-co-glycolide) nanofibrous membranes
作者： Huarong Nie , Aihua He , Charles C. Han
DOI: 10.1039/C3RA22835E
关键词: Polymer chemistry 、 Membrane 、 Bifunctional 、 Chitosan 、 Nanofiber 、 Chelation 、 Aqueous solution 、 PLGA 、 Chemistry 、 Surface modification 、 Chemical engineering 、 General chemistry 、 General Chemical Engineering
摘要: In this work, electrospun poly(lactide-co-glycolide) (PLGA) fibrous membranes were functionalized with radionuclides by surface modification. After the introduction of chitosan and bifunctional ligands (DTPA) on soft hydrolyzed PLGA nanofibrous membranes, more than 80% (90Y) in aqueous solutions attached as labels to target nanofibers. To get a high chelating efficiency without changing physical properties hydrolysis conditions, reactive media for DTPA, time thoroughly investigated. These radionuclide labelled have similar mechanical human tissues. 90Y nanofibers shows desirable stability four half-lives.
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