Human genetics, animal models and computer simulations for studying hypertension☆
作者： Nobuyuki Takahashi , Oliver Smithies
DOI: 10.1016/J.TIG.2004.01.004
关键词: Combined use 、 Human genetics 、 Gene 、 Computational biology 、 Gene targeting 、 Essential hypertension 、 Biology
摘要: Essential hypertension is probably caused by combinations of small quantitative changes in the expression many genes together with environmental factors. In this article, strategies for studying using animal models are summarized emphasis on combined use mouse and computer simulations. We have chosen rennin-angiotensin system as our main example. Future directions research gene targeting also discussed.
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