Role of Host Age and Genotype in Murine Enterotropic Coronavirus Infection

摘要: Enterotropic mouse hepatitis virus (MHV) is probably the most common form of MHV in contemporary laboratory populations, but very little known about its pathogenesis. In spite a large volume literature on MHV, these reports are related to respiratory prototype strains (1, 2). When several and enterotropic were inoculated into infant mice, it became clear that different produced two distinctly patterns disease: respiratory, which disseminated from nasal epithelium multiple target organs; or enterotropic, was largely restricted intestine, with minimal dissemination (3). However, has been poorly characterized because fastidious selective vitro growth characteristics. Host age seems significantly influence outcome disease mice infected (4–11), host genotype may also be important susceptibility (12). These well established factors pathogenesis polytropic The present study systematically examined relative inbred ages have previously shown develop severe (BALB/cByJ) mild (SJL/J) when oronasally MHV-JHM (13). Pilot studies suggested genotypes display differential severity strain Y