Adenosine: an old drug newly discovered.

摘要: Over decades, anesthesiologists have used intravenous adenosine as mainstay therapy for diagnosing or treating supraventricular tachycardia in the perioperative setting. More recently, specific receptor therapeutics gene-targeted mice deficient extracellular production individual receptors became available. These models enabled physicians and scientists to learn more about biologic functions of nucleotide metabolism signaling. Such include signaling effects through expressed by many mammalian tissues; example, vascular endothelia, myocytes, hepatocytes, intestinal epithelia, immune cells. At present, pharmacological approaches modulate are evaluated their potential use medicine, including attenuation acute lung injury; renal, intestinal, hepatic myocardial ischemia; leakage. If these laboratory studies can be translated into clinical practice, receptor-based may become an integral component daily anesthesiology practice.