Matrix metalloprotease triggered bioresponsive drug delivery systems - Design, synthesis and application.

作者: Kira Nultsch , Oliver Germershaus

DOI: 10.1016/J.EJPB.2018.08.010

关键词: Drug releaseDrugMatrix metalloproteasesDrug deliveryComputational biologyComputer scienceProteolytic enzymesSystems design

摘要: … enhanced by loading with free DOX. Like … to trigger a reduction of particle size was also applied using gelatin nanoparticles since MMP-2 and MMP-9 not only hydrolyze specific peptide …

参考文章(94)
Bernhard Witkop, Paul Ehrlich and his Magic bullets--revisited. Proceedings of the American Philosophical Society: Held at Philadelphia for Promoting Useful Knowledge. ,vol. 143, pp. 540- 557 ,(1999)
Shaobo Ruan, Xi Cao, Xingli Cun, Guanlian Hu, Yi Zhou, Yijia Zhang, Libao Lu, Qin He, Huile Gao, Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release Biomaterials. ,vol. 60, pp. 100- 110 ,(2015) , 10.1016/J.BIOMATERIALS.2015.05.006
Pengfei Xu, Qingshuo Meng, Huiping Sun, Qi Yin, Haijun Yu, Zhiwen Zhang, Mi Cao, Yingyi Zhang, Yaping Li, Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer. Biomaterials. ,vol. 64, pp. 10- 20 ,(2015) , 10.1016/J.BIOMATERIALS.2015.06.017
Hye Sung Kim, Sujin Yoon, Young Ju Son, Yeonju Park, Young Mee Jung, Hyuk Sang Yoo, High-yield clicking and dissociation of doxorubicin nanoclusters exhibiting differential cellular uptakes and imaging. Journal of Controlled Release. ,vol. 217, pp. 64- 73 ,(2015) , 10.1016/J.JCONREL.2015.08.037
Benjamin E. Turk, Lisa L. Huang, Elizabeth T. Piro, Lewis C. Cantley, Determination of protease cleavage site motifs using mixture-based oriented peptide libraries Nature Biotechnology. ,vol. 19, pp. 661- 667 ,(2001) , 10.1038/90273
Ulrich Eckhard, Pitter F. Huesgen, Oliver Schilling, Caroline L. Bellac, Georgina S. Butler, Jennifer H. Cox, Antoine Dufour, Verena Goebeler, Reinhild Kappelhoff, Ulrich auf dem Keller, Theo Klein, Philipp F. Lange, Giada Marino, Charlotte J. Morrison, Anna Prudova, David Rodriguez, Amanda E. Starr, Yili Wang, Christopher M. Overall, Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses. Matrix Biology. ,vol. 49, pp. 37- 60 ,(2016) , 10.1016/J.MATBIO.2015.09.003
Marc Sutter, Juergen Siepmann, Wim E. Hennink, Wim Jiskoot, Recombinant gelatin hydrogels for the sustained release of proteins Journal of Controlled Release. ,vol. 119, pp. 301- 312 ,(2007) , 10.1016/J.JCONREL.2007.03.003
Deepali G. Vartak, Richard A. Gemeinhart, Matrix metalloproteases: Underutilized targets for drug delivery Journal of Drug Targeting. ,vol. 15, pp. 1- 20 ,(2007) , 10.1080/10611860600968967
Bratati Ganguly, D. K. Srivastava, Influence of "Flexible" versus "Rigid" Nanoparticles on the Stability of Matrix Metalloproteinase-7. Journal of Biomedical Nanotechnology. ,vol. 4, pp. 457- 462 ,(2008) , 10.1166/JBN.2008.010
Hong-Xia Wang, Xian-Zhu Yang, Chun-Yang Sun, Cheng-Qiong Mao, Yan-Hua Zhu, Jun Wang, None, Matrix metalloproteinase 2-responsive micelle for siRNA delivery. Biomaterials. ,vol. 35, pp. 7622- 7634 ,(2014) , 10.1016/J.BIOMATERIALS.2014.05.050