Autoantibody microarrays for biomarker discovery.

摘要: Identification of autoantigens and the detection autoantibody reactivity are useful in biomarker discovery for explaining role important biochemical pathways disease. Despite all their potential advantages, main challenge to working with autoantibodies is sensitivity. Nevertheless, proteomics may hold key overcoming this limitation by providing means multiplex. Clearly, ability detect multiple using a platform such as high-density antigen microarray would improve sensitivity specificity profiling. The aims review to: briefly describe current status antigen–autoantibody microarrays; provide examples use discoveries; address limitations; strategies facilitate implementation clinical setting.