Genome-wide association study of pathological gambling.

摘要: Abstract Background Pathological gambling is a behavioural addiction with negative economic, social, and psychological consequences. Identification of contributing genes pathways may improve understanding aetiology facilitate therapy prevention. Here, we report the first genome-wide association study pathological gambling. Our aims were to identify involved in gambling, examine whether there genetic overlap between alcohol dependence. Methods Four hundred forty-five individuals diagnosis according Diagnostic Statistical Manual Mental Disorders recruited Germany, 986 controls drawn from German general population sample. A comprising single marker, gene-based, pathway analyses, was performed. Polygenic risk scores generated using data Results No significant found for markers or genes. Pathways Huntington's disease (P-value = 6.63 × 10−3); 5′-adenosine monophosphate-activated protein kinase signalling (P-value = 9.57 × 10−3); apoptosis (P-value = 1.75 × 10−2) significant. score analysis dependence dataset yielded one-sided nominal P-value subjects irrespective comorbid status. Conclusions The present results accord previous quantitative formal studies which showed non-substance- substance-related addictions. Furthermore, suggests shared pathology This finding consistent imaging studies.