Family-Based Association Analysis of Serotonin Genes in Pathological Gambling Disorder: Evidence of Vulnerability Risk in the 5HT-2A Receptor Gene
作者： David Wilson , Daniela Sabbatini da Silva Lobo , Hermano Tavares , Valentim Gentil , Homero Vallada
DOI: 10.1007/S12031-012-9846-X
关键词:
摘要: Pathological gambling (PG) has become a growing public health problem in many countries around the world. PG is an impulse control disorder and its behavior psychopathology present similarities with substance abuse disorders. Evidence from twin studies supports significant genetic predisposition to PG, but precise loci still remain unclear. The study investigates allele genotype distribution of polymorphisms serotonin transporter, receptor 1B 2A genes 140 sib-pairs discordant for diagnosis PG. A association C/C T102C (rs 6313) polymorphism phenotype was observed [OR = 1.7 (1.1–3.4)]. This preliminary result consistent hypothesis that system associated addiction similar results have been reported nicotine alcohol dependence.
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Aviel Goodman, Neurobiology of addiction Biochemical Pharmacology. ,vol. 75, pp. 266- 322 ,(2008) , 10.1016/J.BCP.2007.07.030
Ignacio P??rez de Castro, Angela Ib??nez, Jer??nimo Saiz-Ruiz, Jos?? Fern??ndez-Piqueras, Genetic contribution to pathological gambling: possible association between a functional DNA polymorphism at the serotonin transporter gene (5-HTT) and affected men. Pharmacogenetics. ,vol. 9, pp. 397- 400 ,(1999) , 10.1097/00008571-199906000-00016
R. Andrew Chambers, Marc N. Potenza, Neurodevelopment, impulsivity, and adolescent gambling. Journal of Gambling Studies. ,vol. 19, pp. 53- 84 ,(2003) , 10.1023/A:1021275130071
M. Victòria Puig Velasco, Pau Celada Pedrosa, Francesc Artigas Pérez, Control serotoninérgico de la corteza prefrontal Revista De Neurologia. ,vol. 39, pp. 539- 547 ,(2004) , 10.33588/RN.3906.2004433
Howard J. Shaffer, Matthew N. Hall, Updating and refining prevalence estimates of disordered gambling behaviour in the United States and Canada Canadian Journal of Public Health-revue Canadienne De Sante Publique. ,vol. 92, pp. 168- 172 ,(2001) , 10.1007/BF03404298
RJ Rosenthal, DE Comings, R Gade-Andavolu, N Gonzalez, S Wu, D Muhleman, C Chen, P Koh, K Farwell, H Blake, G Dietz, JP MacMurray, HR Lesieur, LJ Rugle, The additive effect of neurotransmitter genes in pathological gambling Clinical Genetics. ,vol. 60, pp. 107- 116 ,(2008) , 10.1034/J.1399-0004.2001.600204.X
N Laurin, Y Feng, A Ickowicz, T Pathare, M Malone, R Tannock, R Schachar, J L Kennedy, C L Barr, No preferential transmission of paternal alleles at risk genes in attention-deficit hyperactivity disorder. Molecular Psychiatry. ,vol. 12, pp. 226- 229 ,(2007) , 10.1038/SJ.MP.4001936
Melanie J. White, Ross McD. Young, C. Phillip Morris, Bruce R. Lawford, Cigarette smoking in young adults: the influence of the HTR2A T102C polymorphism and punishment sensitivity. Drug and Alcohol Dependence. ,vol. 114, pp. 140- 146 ,(2010) , 10.1016/J.DRUGALCDEP.2010.08.014
Hai-Gwo Hwu, Chia-Hsiang Chen, Association of 5HT2A receptor gene polymorphism and alcohol abuse with behavior problems. American Journal of Medical Genetics. ,vol. 96, pp. 797- 800 ,(2000) , 10.1002/1096-8628(20001204)96:6<797::AID-AJMG20>3.0.CO;2-K
EH Cook Jr, R Courchesne, C Lord, N J Cox, S Yan, A Lincoln, R Haas, E Courchesne, B L Leventhal, Evidence of linkage between the serotonin transporter and autistic disorder Molecular Psychiatry. ,vol. 2, pp. 247- 250 ,(1997) , 10.1038/SJ.MP.4000266