Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain
作者： Tetsuya Ikeda , Yasushi Ishida , Rumi Naono , Ryuichiro Takeda , Hiroshi Abe
DOI: 10.1016/J.NEURES.2008.10.002
关键词: Anesthesia 、 Tricyclic 、 Threshold of pain 、 Milnacipran 、 Fluvoxamine 、 Diabetic neuropathy 、 Nociception assay 、 Medicine 、 Neuropathic pain 、 Pharmacology 、 Hyperalgesia
摘要: Antidepressants, especially tricyclic antidepressants (TCAs) are widely used for the treatment of various types chronic and neuropathic pain. The antinociceptive effects TCAs are, however, complicated. Therefore, two kinds newer whose functions have been more fully clarified were selected, milnacipran, a serotonin noradrenaline reuptake inhibitor (SNRI) paroxetine fluvoxamine, which selective inhibitors (SSRIs). antiallodynic intrathecal administration these examined in rat models pain, constriction injury (CCI) sciatic nerve streptozotocin (STZ)-induced diabetic neuropathy. effect was evaluated using von Frey test. milnacipran had an both CCI STZ-induced rats dose-dependent manner. On other hand, either or fluvoxamine elicited little rats, while SSRIs These results indicate considerable difference to exist development and/or maintenance between animal pain suggest that each three may be effective
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