Diversity of the African swine fever virus genome.

摘要: African swine fever is caused by a cytoplasmically located virus particle that, although structurally similar to the Iridoviridae, has number of similarities with Poxviridae. The genomes (ASFV) isolates from ticks inhabiting warthog burrows in different areas Zambia were genetically very diverse. Differences between neighbouring also detected and probably resulted point mutations that had occurred at various positions along genome. domestic pig outbreaks two regions where disease endemic (Europe/W. Africa E. Zambia/Malawi) compared. Genomes viruses within each these closely related other usually varied as result additions or deletions sequences close both termini. Restriction enzyme mapping defined seven genome length variations occurred. In most quite small (<2kb) but region 7 20kb left hand terminus large (up 9kb) found. Two variable contained tandemly repeated sequences. results are discussed terms selective constraints imposed replication warthogs compared populations.