Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis.
作者： Martin Leverkus , Henning Walczak , Alex McLellan , Hans-Werner Fries , Gabi Terbeck
关键词: Fas receptor 、 Caspase 8 、 Antigen-presenting cell 、 Biology 、 Cell biology 、 Tumor necrosis factor alpha 、 Antigen presentation 、 Immunology 、 Dendritic cell 、 Apoptosis 、 Programmed cell death
摘要: Dendritic cells (DCs) disappear from lymph nodes 1 to 2 days after antigen presentation, presumably by apoptosis. To evaluate the role of death ligands in elimination DCs, we analyzed sensitivity human DCs CD95 ligand (CD95L) and tumor necrosis factor-related apoptosis-inducing (TRAIL). We found mature be resistant killing via CD95L or TRAIL, whereas only immature were partially sensitive. However, all DC populations expressed CD95, TRAIL-R2, TRAIL-R3 at comparable levels, suggesting that ligand-induced apoptosis is not regulated receptor level. Interestingly, highly caspase 8 inhibitory protein cFLIP, low levels detected DCs. Thus, proved dependent on maturation inversely correlated with expression cFLIP. Induction TRAIL does seem play a but instead might serve regulate populations.
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