5-HTTLPR/rs25531 polymorphism and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus

摘要: The s/s-genotype of the 5-HTTLPR polymorphism and personality trait of neuroticism have both been associated with experiences negative affect, anxiety mood disorders, as well as an emotional processing bias towards facial emotions. On a neural level, this can be characterized by altered amygdala fusiform gyrus (FFG) activity during perception expressions. Using resting-state functional magnetic resonance imaging in multi-center-sample 178 healthy subjects European descent, study investigated association (short s- long l-allele) including genotype single nucleotide (SNP) rs25531 (A/G) within region polymorphism, on connectivity (rs-FC) between FFG. Moreover, we aimed to identify additional brain regions associations 5-HTTLPR/rs25531 (combined according its expression; low: s/s; high: lA/lA; intermediate: s/lA, s/lG, lG/lG, lA/lG) rs-FC. Separate analyses for (controlling age, gender, handedness, research site) revealed that s/s-homozygotes individuals high obtained rs-FC right occipital face area, which is considered “core component” system. Importantly, effects were replicated across three independent sites. Additionally, observed anterior posterior cingulate cortex, whereas was not related these areas. presented data implies variants are linked resting state suggests different levels may partly account