Copper oxide nanoparticles inhibit the metabolic activity of Saccharomyces cerevisiae
作者： Michael J. Mashock , Anthony D. Kappell , Nadia Hallaj , Krassimira R. Hristova
DOI: 10.1002/ETC.3159
关键词: Copper oxide 、 Nanotoxicology 、 Nanoparticle 、 Saccharomyces cerevisiae 、 Nanostructure 、 Chemistry 、 Viability assay 、 Dissolution 、 Copper oxide nanoparticles 、 Nuclear chemistry 、 Nanotechnology
摘要: Copper oxide nanoparticles (CuO NPs) are used increasingly in industrial applications and consumer products thus may pose risk to human environmental health. The interaction of CuO NPs with complex media the impact on cell metabolism when exposed sublethal concentrations largely unknown. In present study, short-term effects 2 different sized manufactured metabolic activity Saccharomyces cerevisiae were studied. role released Cu2+ during dissolution growth nanostructure considered. Characterization showed that 28 nm 64 nm study have primary diameter, similar hydrodynamic significantly dissolved ions from same initial NP mass. Exposures or fraction, at doses do not viability, significant inhibition S. cellular activity. A greater effect under respiring conditions was observed. Under tested observed explained fully by Cu dissolving NPs. Environ Toxicol Chem 2016;35:134–143. © 2015 SETAC
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