Production of pyrans, pyridazines, pyrimidines, pyrazines and triazine compounds using benzoylacetonitriles as a precursor

作者: Bakr F. Abdel-Wahab , Mohamed F. El-Mansy , Rizk E. Khidre

DOI: 10.1007/S13738-013-0244-2

关键词: NitrileTriazineChemistryMethyleneOrganic chemistryGeneral chemistry

摘要: Benzoylacetonitriles are easily available and have high chemical reactivity due to the presence of three active moieties; nitrile, carbonyl, methylene functions. This review article represents a survey covering synthetic strategies leading five six-membered heterocycles; pyrans, pyridazines, pyrimidines, pyrazines, triazine compounds; utilizing benzoylacetonitriles as starting precursor since 1985. The reactions subdivided into groups that cover methods these heterocycles.

参考文章(64)
Ahmed Hafez Hussien Elghandour, Mahmoud Mohamed Mahfouz Ramiz, Mohamed Hilmy Elnagdi, None, Novel Synthesis of Polyfunctionally Substituted Pyridines and Pyrimidines Synthesis. ,vol. 1989, pp. 775- 777 ,(1989) , 10.1055/S-1989-27393
Hassan Attia Elfahham, Galal Eldin Hamza Elgemeie, Yusria Rizk Ibraheim, Mohamed Hilmy Elnagdi, Studies on 3,5‐diaminopyrazoles: New routes for the synthesis of new pyrazoloazines and pyrazoloazoles European Journal of Organic Chemistry. ,vol. 1988, pp. 819- 822 ,(1988) , 10.1002/JLAC.198819880820
Esther Vicente, Pablo R Duchowicz, Diego Benítez, Eduardo A Castro, Hugo Cerecetto, Mercedes González, Antonio Monge, None, Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2-carbonitrile di-N-oxides. Bioorganic & Medicinal Chemistry Letters. ,vol. 20, pp. 4831- 4835 ,(2010) , 10.1016/J.BMCL.2010.06.101
Fathy Mohamed Abdelrazek, Zaghloul El-Shahat Kandeel, Khalid Mohamed Hassan Himly, Mohamed Hilmy Elnagdi, None, SUBSTITUTED ACRYLONITRILES IN HETEROCYCLIC SYNTHESIS. THE REACTION OF α-SUBSTITUTED β-(2-FURYL)ACRYLONITRILES WITH SOME ACTIVE METHYLENE HETEROCYCLES Synthesis. ,vol. 1985, pp. 432- 434 ,(1985) , 10.1055/S-1985-31232
Hamad M. Al-Matar, Khaled D. Khalil, Aisha Y. Adam, Mohamed H. Elnagdi, Green One Pot Solvent-Free Synthesis of Pyrano[2,3-c]-Pyrazoles and Pyrazolo[1,5-a]Pyrimidines Molecules. ,vol. 15, pp. 6619- 6629 ,(2010) , 10.3390/MOLECULES15096619
Na Li, Shiu-Lun Lai, Weimin Liu, Pengfei Wang, Juanjuan You, Chun-Sing Lee, Zengtao Liu, Synthesis and properties of n-type triphenylpyridine derivatives and applications in deep-blue organic light-emitting devices as electron-transporting layer Journal of Materials Chemistry. ,vol. 21, pp. 12977- 12985 ,(2011) , 10.1039/C1JM11898F
Galal H. Elgemeie, Ahmed H. Elghandour, Hamdy M. Elshimy, Studies on aminoazoles: Synthesis of Pyrazolo[1,5‐a]‐pyrimidines and their aza derivatives Journal Fur Praktische Chemie-chemiker-zeitung. ,vol. 331, pp. 466- 474 ,(1989) , 10.1002/PRAC.19893310318
Nadia S. Ibrahim, Kamal U. Sadek, Fatma A. Abdel-Al, Studies on 3,5-Diaminopyrazoles: Synthesis of New Polyfunctionally Substituted Pyrazoloazines and Pyrazoloazoles Archiv der Pharmazie. ,vol. 320, pp. 240- 246 ,(1987) , 10.1002/ARDP.19873200310
Terry V. Hughes, Stuart L. Emanuel, Amanda K. Beck, Steven K. Wetter, Peter J. Connolly, Prabha Karnachi, Michael Reuman, Jabed Seraj, Angel R. Fuentes-Pesquera, Robert H. Gruninger, Steven A. Middleton, Ronghui Lin, Jeremy M. Davis, David F.C. Moffat, 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation Bioorganic & Medicinal Chemistry Letters. ,vol. 17, pp. 3266- 3270 ,(2007) , 10.1016/J.BMCL.2007.04.021