A method to increase the excretion of non-sterol endogenous hydrophobic substances by increasing excretion of fat via the faeces

作者: Hendrik Jan Verkade

DOI:

关键词: LipstatinErythropoietic protoporphyriaOlestraChemistryBiochemistrySterolProtoporphyrinExcretionEndogenyPolyol

摘要: The subject invention concerns a method to increase the excretion of non-sterol endogenous hydrophobic substances or metabolic derivatives thereof by increasing via faeces substance derivative characterisedin that fat is increased. purpose prevent treat conditions associated with accumulation thereof, such being unconjugated bilirubin and protoporphyrin. More particularly, lipstatin, orlistat, tetrahydrolipstatin, polyol fatty acids like olestra, non-conventional doses dietary jet are used neonatal jaundice, haemolytic erythropoietic protoporphyria.

参考文章(9)
Paul J. Soltys, Robert S. Langer, Claudy J. P. Mullon, Oral bilirubin therapy ,(1990)
Wael F. Sunnoqrot, Bassam M. El-Wadi, Husni H. Abu Seir, Different way of management of neonatal hyperbilirubinemia ,(1996)
Oscar W. Portman, Manfred Alexander, Charles E. Cornelius, Jayanta Roy Chowdhury, Namita Roy Chowdhury, Irwin M. Arias, Effects of Nutrition on Unconjugated Plasma Bilirubin Concentrations in Squirrel Monkeys Hepatology. ,vol. 4, pp. 454- 460 ,(1984) , 10.1002/HEP.1840040318
Pius Hildebrand, Christophe Petrig, Beat Burckhardt, Silvia Ketterer, Hans Lengsfeld, André Fleury, Paul Hadváry, Christoph Beglinger, Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release Gastroenterology. ,vol. 114, pp. 123- 129 ,(1998) , 10.1016/S0016-5085(98)70640-7
George S. Drummond, Attallah Kappas, Control of heme and iron concentrations in body tissues ,(1986)
U. Siigur, K. E. Norin, G. Allgood, T. Schlagheck, T. Midtvedt, Effect of Olestra Upon Intestinal Microecology as Reflected by Five Microflora Associated Characteristics in Man Microbial Ecology in Health and Disease. ,vol. 9, pp. 295- 303 ,(1996) , 10.3109/08910609609166470
W. Schwizer, K. Asal, C. Kreiss, C. Mettraux, J. Borovicka, B. Remy, C. Guzelhan, D. Hartmann, M. Fried, Role of lipase in the regulation of upper gastrointestinal function in humans American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 273, ,(1997) , 10.1152/AJPGI.1997.273.3.G612
Joseph J. Nagyvary, Method for treating hyperbilirubinemia ,(1981)