Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
作者： Daniel J. Rader
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摘要: The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of MTP inhibitor inhibit in said subject, wherein administration comprises escalating series doses inhibitor. In some embodiments method at least three step-wise, increasing dosages subject. embodiments, further one or more other lipid modifying compounds.
lens.org参考文章(151)
Verica Risovic, Kishor M Wasan, Daniel Debeyer, David J Stewart, James Kutney, Norbert A Looije, Disodium Ascorbyl Phytostanyl Phosphates (FM-VP4) reduces plasma cholesterol concentration, body weight and abdominal fat gain within a dietary-induced obese mouse model. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences. ,vol. 8, pp. 400- 408 ,(2005)
Stefan Dr. Wohlfeil, Hilmar Dr. Bischoff, Peter Dr. Kolkhof, Rudi Dr. Grützmann, Stefan Dr. Lohmer, Dirk Dr. Denzer, Ulrich Dr. Müller, Peter Dr. Eckenberg, Ulrich Dr. Nielsch, Pyrimido [1,2-a] indoles ,(1997)
Takeshi Iwata, Information display apparatus and display control method ,(2005)
Scott M. Grundy, Donald B. Hunninghake, Russell V. Luepker, James M. McKenney, Richard C. Pasternak, Patrick McBride, Richard S. Cooper, Neil J. Stone, Diane Becker, Luther T. Clark, Linda Van Horn, James Howard, D. Roger Illingworth, Margo A. Denke, Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) Circulation. ,vol. 106, pp. 3143- 3421 ,(2002)
Giancarlo Ghiselli, Dino Severino, Pierpaolo Lovisolo, Augusto Chiari, Daniele Fancelli, Phosphate derivatives of disubstituted ureas and thioureas ,(1996)
Shogo Yamane, Hirofumi Yamane, Masaki Sunami, Solid medicinal preparation improved in solubility and stability and process for producing the same ,(2005)
Ernest Seiichi Hamanaka, George Chang, Lowering blood levels of lipoprotein(a) ,(1999)
Hiroshi Moritani, Masanori Miura, Akira Suga, Daisuke Sasuga, Hideki Kubota, Agent enhancing lipid-loewring effect ,(2004)
Andreas Geerts, Ulf Brüggemeier, Stefan Golz, Diagnostics and therapeutics for diseases associated with rho-associated protein kinase 1 (rock1) ,(2005)