Non-enzymatic lipid peroxidation of microsomes and mitochondria from liver, heart and brain of the bird Lonchura striata: relationship with fatty acid composition.
作者： Ana María Gutiérrez , Guillermo Raúl Reboredo , Susana María Mosca , Angel Catalá
DOI: 10.1016/J.CBPA.2006.11.018
关键词: Lipid peroxidation 、 Unsaturated fatty acid 、 Microsome 、 Arachidonic acid 、 Biology 、 Heart metabolism 、 Mitochondrion 、 Biochemistry 、 Fatty acid 、 Polyunsaturated fatty acid
摘要: The aim of this study was to examine the fatty acid composition and non-enzymatic lipid peroxidation (LP) mitochondria microsomes obtained from liver, heart brain Lonchura striata. percentage total unsaturated approximately 30-60% in organelles all tissues studied. Brain both liver exhibited highest polyunsaturated (PUFA) (30 18%, respectively). arachidonic (AA) content 7% 3% mitochondria. docosahexanoic (DHA) 8% 2-3% peroxidizability index (PI) higher than that microsomes. Liver were affected by LP, as indicated increase chemiluminescence a decrease AA DHA. These changes not observed during LP heart. results indicate: 1) PI positively correlates with PUFA LP; 2) resistance detected would contribute cardiac protection against oxidative damage.
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