Blood vessel replacement: 50 years of development and tissue engineering paradigms in vascular surgery.
作者： J Chlupáč , E Filová , L Bačáková
DOI: 10.33549/PHYSIOLRES.931918
关键词: Thrombogenicity 、 Medicine 、 Vein graft disease 、 Artery 、 Bypass surgery 、 Surgery 、 Vascular Patency 、 Blood vessel 、 Vascular surgery 、 Intimal hyperplasia
摘要: The gold standard material in bypass surgery of blood vessels remains the patient's own artery or vein. However, this may be unavailable, suffer vein graft disease. Currently available vascular prostheses, namely polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE), perform well as large-caliber replacements, but their long-term patency is discouraging small-caliber applications (<6 mm), such coronary, crural microvessel surgery. This failure mainly a result an unfavorable healing process with surface thrombogenicity, due to lack endothelial cells anastomotic intimal hyperplasia caused by hemodynamic disturbances. An ideal small-diameter has become major focus research. Novel biomaterials have been manufactured, tissue-biomaterial interactions optimized. Tissue engineering technology proven that concept partially totally living feasible. purpose review outline materials are currently being implanted, taking into account cell-biomaterial physiology, tissue approaches collective achievements authors.
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