Plasmodium falciparum maturation abolishes physiologic red cell deformability
作者： H. Cranston , C. Boylan , G. Carroll , S. Sutera , Williamson
关键词: Blood viscosity 、 Spleen 、 In vitro 、 Red blood cell 、 Biology 、 Cell biology 、 Rheoscope 、 Plasmodium falciparum 、 Red Cell 、 Immune system 、 Immunology
摘要: Normal red cells deform markedly as they pass through the spleen and peripheral capillaries. In these studies, effects of Plasmodium falciparum infection maturation on deformability parasitized exposed to fluid shear stress in vitro were examined by means a rheoscope. Red containing early (ring) erythrocytic stage parasite have impaired at physiologic stresses, recover their normal shape more slowly. mature parasites (trophozoites or schizonts) exhibit no deformation under same conditions. These results provide mechanism explain ability remove from circulation both immune nonimmune hosts.
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