Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?
作者： Hilary S. Gammill , Katherine A. Guthrie , Tessa M. Aydelotte , Kristina M. Adams Waldorf , J. Lee Nelson
DOI: 10.1182/BLOOD-2010-02-270942
关键词: Immunology 、 Pregnancy 、 Cord Blood Stem Cell Transplantation 、 Internal medicine 、 Hematology 、 Biology 、 Fetus 、 Transplantation 、 Andrology 、 Odds ratio 、 Chimera (genetics) 、 Microchimerism
摘要: Small amounts of genetically foreign cells (microchimerism, Mc) traffic between a mother and fetus during pregnancy. Commonly, these grafts durably persist. For women, multiple naturally acquired Mc can accrue, as they harbor from their own mothers (maternal Mc, MMc) subsequently acquire fetal (FMc) through The nature interactions may inform, be informed by, observations in transplantation, including the effect noninherited maternal HLA antigens (NIMA) double-unit cord blood transplantation (CBT). We asked whether FMc MMc are impacted by addition new evaluated increasing parity. was identified quantitative PCR for nonshared polymorphism unique to source. Despite sources did not increase with concentration significantly lower odds ratio detection 2 or more births compared 1 birth .11 (95% CI 0.03-0.42, P = .001). These suggest that occur among interest light recent graft-graft interaction resulting predominance unit CBT correlation NIMA effect.
ashpublications.org
bloodjournal.org
scienceopen.com
researchgate.net 参考文章(51)
Paul C. Evans, Nathalie Lambert, Sean Maloney, Dan E. Furst, James M. Moore, J. Lee Nelson, Long-Term Fetal Microchimerism in Peripheral Blood Mononuclear Cell Subsets in Healthy Women and Women With Scleroderma Blood. ,vol. 93, pp. 2033- 2037 ,(1999) , 10.1182/BLOOD.V93.6.2033.406K18_2033_2037
Karin Ekström, Joanne Wuu, Chung‐Cheng Hsieh, Bengt Glimelius, Mats Lambe, Childbearing and the risk of leukemia in Sweden Cancer Causes & Control. ,vol. 13, pp. 47- 53 ,(2002) , 10.1023/A:1013917610685
Meir J. Stampfer, Dominique S. Michaud, Walter C. Willett, Edward L. Giovannucci, Graham A. Colditz, Charles S. Fuchs, Halcyon G. Skinner, Parity, reproductive factors, and the risk of pancreatic cancer in women. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 12, pp. 433- 438 ,(2003)
Erik J. Novak, Andrew W. Liu, Gerald T. Nepom, William W. Kwok, MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen. Journal of Clinical Investigation. ,vol. 104, ,(1999) , 10.1172/JCI8476
Jonathan A. Gutman, Cameron J. Turtle, Thomas J. Manley, Shelly Heimfeld, Irwin D. Bernstein, Stanley R. Riddell, Colleen Delaney, Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit Blood. ,vol. 115, pp. 757- 765 ,(2010) , 10.1182/BLOOD-2009-07-228999
M. Lambe, M. Thörn, P. Sparen, R. Bergströrn, H. -O. Adami, Malignant melanoma: reduced risk associated with early childbearing and multiparity. Melanoma Research. ,vol. 6, pp. 147- 154 ,(1996) , 10.1097/00008390-199604000-00010
R. E. BILLINGHAM, L. BRENT, P. B. MEDAWAR, ‘Actively Acquired Tolerance’ of Foreign Cells Nature. ,vol. 172, pp. 603- 606 ,(1953) , 10.1038/172603A0
H Schoemans, K Theunissen, J Maertens, M Boogaerts, C Verfaillie, J Wagner, Adult umbilical cord blood transplantation: a comprehensive review Bone Marrow Transplantation. ,vol. 38, pp. 83- 93 ,(2006) , 10.1038/SJ.BMT.1705403
Anne M Stevens, W Michael McDonnell, Meghan E Mullarkey, Jennifer M Pang, Wendy Leisenring, J Lee Nelson, Liver biopsies from human females contain male hepatocytes in the absence of transplantation. Laboratory Investigation. ,vol. 84, pp. 1603- 1609 ,(2004) , 10.1038/LABINVEST.3700193
Vijayakrishna K. Gadi, Kathleen E. Malone, Katherine A. Guthrie, Peggy L. Porter, J. Lee Nelson, Case-control study of fetal microchimerism and breast cancer. PLOS ONE. ,vol. 3, ,(2008) , 10.1371/JOURNAL.PONE.0001706