Parity, reproductive factors, and the risk of pancreatic cancer in women.

摘要: Incidence rates for pancreatic cancer are consistently lower in women than men. Previous studies suggest that reproductive factors, particularly parity, may reduce risk women. We examined breast feeding history, age at first birth, menstrual and exogenous hormone use relation to a prospective cohort study of Information on parity other factors was assessed by questionnaires 1976 updated biennially. Multivariate relative risks were adjusted cigarette smoking, body mass index, diabetes, height. During 22 years follow-up (1976–1998), 115,474 contributed 2.4 million person time, 243 cases identified. Compared with nulliparous women, the 0.86 [95% confidence interval (CI), 0.55–1.36] 1–2 births, 0.75 (95% CI, 0.48–1.17) 3–4 0.58 0.34–0.98) those ≥5 births after adjusting factors. An analysis linear trend indicates 10% reduction each birth (Ptrend = 0.008). Other not significantly related risk. In this large associated reduced cancer. Additional should examine physiological or hormonal changes underlying pregnancy childbirth explain finding.