Determination of cationic neurotransmitters and metabolites in brain homogenates by microchip electrophoresis and carbon nanotube-modified amperometry.
作者： Markéta Vlčková , Maria A. Schwarz
DOI: 10.1016/J.CHROMA.2006.12.040
关键词: Electrophoresis 、 Amperometry 、 Sodium dodecyl sulfate 、 Micelle 、 Chemistry 、 Capillary electrophoresis 、 Metabolite 、 Detection limit 、 Chromatography 、 Working electrode
摘要: An electrophoretic method for simultaneous determination of catecholamines and their O-methoxylated metabolites on the microchip as well in capillary is presented. A complex separation system employing sodium dodecyl sulfate (SDS) micelles, dendrimers forming a second pseudostationary phase borate complexation needed satisfactory selected compounds short migration length. carbon nanotube-modified working electrode has been applied sensitive amperometric detection with submicromolar limits. The applicability this new analytics real samples demonstrated by analysis mouse brain homogenate human urine electrophoresis.
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