Nanoparticle Delivery of miR-708 Mimetic Impairs Breast Cancer Metastasis.

摘要: Triple-negative breast cancer (TNBC) patients exhibit the worst clinical outcome due to its aggressive course, higher rate of recurrence, and a conspicuous lack FDA-approved targeted therapies. Here, we show that multilayered nanoparticles (NPs) carrying metastasis suppressor microRNA miR-708 (miR708-NP) localize orthotopic primary TNBC, efficiently deliver cargo reduce lung metastasis. Using SOX2/OCT4 promoter reporter, identified population miR-708low cells with tumor-initiating properties, enhanced metastatic potential, marked sensitivity treatment. In vivo, miR708-NP directly SOX2/OCT4-mCherry+ tumor impair Together, our preclinical findings provide mechanism-based antimetastatic therapeutic approach for potential generate replacement therapy high-risk TNBC in clinic. To knowledge, this gold nanoparticle-based delivery mimetic is first oligonucleotide-based TNBC.