Redox Regulation of Cytokine Expression in Kupffer Cells
DOI: 10.1089/152308602760598882
关键词: Liver injury 、 Redox 、 Promoter 、 Immunology 、 Mechanism (biology) 、 Cell biology 、 Homeostasis 、 Liver damage 、 Cytokine expression 、 Transcription factor 、 Biology 、 Clinical biochemistry 、 Biochemistry 、 Physiology 、 Molecular biology
摘要: Kupffer cells, resident macrophages in the liver, play a central role homeostatic response to liver injury. Ironically, this defensive mechanism, if dysregulated, also works against acute and chronic damage. Central is activation of nuclear factor-κB (NF-κB), redox-sensitive transcription factor that transactivates promoters many inflammatory genes, including cytokines. Much research has been devoted identification upstream signaling for NF-κB, but precise mechanism by which oxidant stress participates yet be determined. Clues key question may attained through studies on mechanisms sustained and/or accentuated NF-κB hepatic diseases. This article reviews literature redox regulation cytokine gene expression cells.
liebertonline.com参考文章(63)
I. D. Ratnayaka, R. D. Goldin, S. N. Wickramasinghe, I. N. Brown, The effect of Kupffer cell elimination on ethanol-induced liver damage in mice. International Journal of Experimental Pathology. ,vol. 76, pp. 353- 359 ,(1995)
K. Schulze-Osthoff, R. Beyaert, V. Vandevoorde, G. Haegeman, W. Fiers, Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. The EMBO Journal. ,vol. 12, pp. 3095- 3104 ,(1993) , 10.1002/J.1460-2075.1993.TB05978.X
Ralf Schreck, Patrick A. Baeuerle, [14] Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-κB Methods in Enzymology. ,vol. 234, pp. 151- 163 ,(1994) , 10.1016/0076-6879(94)34085-4
X Wu, N H Bishopric, D J Discher, B J Murphy, K A Webster, Physical and functional sensitivity of zinc finger transcription factors to redox change. Molecular and Cellular Biology. ,vol. 16, pp. 1035- 1046 ,(1996) , 10.1128/MCB.16.3.1035
Masahiro Arai, Satoshi Mochida, Akihiko Ohno, Itsuro Ogata, Kenji Fujiwara, Sinusoidal endothelial cell damage by activated macrophages in rat liver necrosis Gastroenterology. ,vol. 104, pp. 1466- 1471 ,(1993) , 10.1016/0016-5085(93)90357-I
Daniell B Hill, Radhika Devalaraja, Swati Joshi-Barve, Shirish Barve, Craig J McClain, Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro Clinical Biochemistry. ,vol. 32, pp. 563- 570 ,(1999) , 10.1016/S0009-9120(99)00056-9
Masao Saitoh, Hideki Nishitoh, Makiko Fujii, Kohsuke Takeda, Kei Tobiume, Yasuhiro Sawada, Masahiro Kawabata, Kohei Miyazono, Hidenori Ichijo, Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. The EMBO Journal. ,vol. 17, pp. 2596- 2606 ,(1998) , 10.1093/EMBOJ/17.9.2596
Klaus Tschaikowsky, Joseph D. Brain, Effects of liposome-encapsulated dichloromethylene diphosphonate on macrophage function and endotoxin-induced mortality. Biochimica et Biophysica Acta. ,vol. 1222, pp. 323- 330 ,(1994) , 10.1016/0167-4889(94)90037-X
Quan Zhao, Frank S. Lee, Mitogen-activated Protein Kinase/ERK Kinase Kinases 2 and 3 Activate Nuclear Factor-κB through IκB Kinase-α and IκB Kinase-β Journal of Biological Chemistry. ,vol. 274, pp. 8355- 8358 ,(1999) , 10.1074/JBC.274.13.8355
Y. Xia, C. Makris, B. Su, E. Li, J. Yang, G. R. Nemerow, M. Karin, MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 5243- 5248 ,(2000) , 10.1073/PNAS.97.10.5243