Post-acute serum eosinophil and neutrophil-associated cytokine/chemokine profile can distinguish between patients with neuromyelitis optica and multiple sclerosis; and identifies potential pathophysiological mechanisms - a pilot study.

摘要: Neuromelitis optica (NMO) is an inflammatory, demyelinating disease of the central nervous system. It distinguished from multiple sclerosis (MS) by clinical and radiological features presence aquaporin 4 antibodies in approximately 70%. Despite discovery these evidence neutrophils eosinophils CNS parenchyma, immunopathogenesis NMO remains poorly understood. Previous studies attempting to assess role cytokines chemokines have primarily been conducted acute cerebrospinal fluid East Asian cohorts, assessed small numbers mediators isolation not accounted for important confounding factors including antibody status severity. Therefore we a study more extensive range associated post-acute serum UK cohort using unsupervised multivariate analytical techniques relative concentration concert. Our 29 patients (aquaporin positive n = 19, MS 10), matched where possible, severity, has identified confirmed some key cytokine/chemokine markers distinct MS. findings shed further light on importance specific inflammatory with predominant function differentiation, chemotaxis activity eosinophils, particularly CCL4, CCL11, granulocyte-colony stimulating factor myeloperoxidase, may represent potential immunomodulatory targets.