Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011.

摘要: Livestock constitutes a potential reservoir of meticillin-resistant Staphylococcus aureus isolates belonging to recently derived lineage within clonal complex 398 (MRSA CC398-IIa). Since its discovery in the early 2000s, this has become major cause human disease Europe, posing serious public health challenge countries with intensive livestock production. To retrace history colonisation and infection MRSA CC398-IIa Denmark, we conducted nationwide, retrospective study collected from 1999 2011. Among 7,429 screened, identified 416 isolates. Of these, 148 were people infections, including 51 patients reporting no exposure. The first cases Denmark occurred 2004. Subsequently, incidence showed linear annual increase 66% 2004 2011 (from 0.09 1.1 per 100,000 person-years). There clear temporal spatial relationships between CC398-IIa-infected without These findings suggest substantial dissemination or workers into Danish community underscore need for strategies control spread both on off farm.