Involvement of MAPK/NF-κB Signaling in the Activation of the Cholinergic Anti-Inflammatory Pathway in Experimental Colitis by Chronic Vagus Nerve Stimulation
作者： Peng Sun , Kewen Zhou , Sheng Wang , Ping Li , Sijuan Chen
DOI: 10.1371/JOURNAL.PONE.0069424
关键词: Colitis 、 Inflammation 、 Vagus nerve stimulation 、 Autonomic nervous system 、 Cholinergic anti-inflammatory pathway 、 Immunology 、 Lipopolysaccharide 、 Acetylcholine 、 Pharmacology 、 Inflammatory bowel disease 、 Medicine
摘要: Background Autonomic nervous system dysfunction is implicated in the etiopathogenesis of inflammatory bowel diseases (IBD). Therapies that increase cardiovagal activity, such as Mind-Body interventions, are currently confirmed to be effective clinical trials IBD. However, a poor understanding pathophysiological mechanisms limits popularization therapies practice. The aim present study was explore these against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rats using chronic vagus nerve stimulation model vivo, well lipopolysaccharide (LPS)-induced response human epithelial colorectal adenocarcinoma cells (Caco-2) by acetylcholine vitro.
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