Upgrading the Gleason Score in Extended Prostate Biopsy: Implications for Treatment Choice
作者： Katia Ramos Moreira Leite , Luiz HA Camara-Lopes , Marcos F Dall'Oglio , Jose Cury , Alberto A Antunes
DOI: 10.1016/J.IJROBP.2008.04.039
关键词: Prostate cancer 、 Prostate biopsy 、 Biopsy 、 Prostatectomy 、 Gynecology 、 Retrospective cohort study 、 Urology 、 Medicine 、 Multivariate analysis 、 Prostate 、 Incidence (epidemiology) 、 Cancer research 、 Oncology 、 Radiation 、 Radiology Nuclear Medicine and imaging
摘要: Purpose To determine the incidence of overestimation Gleason score (GS) in extended prostate biopsy, and consequently circumventing unnecessary aggressive treatment. Methods Materials This is a retrospective study 464 patients who underwent biopsy radical prostatectomy between January 2001 November 2007. The GS from were compared. biopsies tumor volume studied. Multivariate analysis was applied to find parameters that predict upgrading biopsy. Results exact agreement occurred 56.9% cases. In 29.1% cases it underestimated, overestimated 14%. One hundred six (22.8%) received diagnosis high (8, 9, or 10) 29.2% cases, definitive Score 7 lower. which tumors significantly smaller. multivariate analysis, total percentage only independent factor GS. Tumors occupying less than 33% cores had 5.6-fold greater chance being overestimated. Conclusion era after International Society Urological Pathology consensus on GS, almost one third considered have at may be intermediate-risk cancers. condition, are smaller should remembered by professionals involved with cancer avoid overtreatment undesirable side effects.
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