PROSTACYCLIN: HAEMODYNAMIC AND METABOLIC EFFECTS IN PATIENTS WITH CORONARY ARTERY DISEASE

作者: G. Bergman , L. Atkinson , P.T. Richardson , K. Daly , M. Rothman

DOI: 10.1016/S0140-6736(81)92028-6

关键词: Coronary artery diseaseAnesthesiaHemodynamicsPlatelet aggregationIntravenous InfusionsMetabolic effectsIn patientCardiologyProstacyclinInternal medicineAnginaMedicineGeneral Medicine

摘要: Abstract The therapeutic potential of prostacyclin was evaluated in 10 patients with angina pectoris and angiographically proven coronary artery disease. Platelet aggregation systemic haemodynamic effects were examined before after intravenous infusions 2, 4, 6, 8 ng/kg/min dose related. At the ADP concentration required to induce 50% maximum platelet increased from 1·8 4·5 μmol/l (p 2 , respectively -5

参考文章(13)
MIGUEL A. CHIONG, ROXROY O. WEST, JOHN O. PARKER, Influence of Nitroglycerin on Myocardial Metabolism and Hemodynamics during Angina Induced by Atrial Pacing Circulation. ,vol. 45, pp. 1044- 1056 ,(1972) , 10.1161/01.CIR.45.5.1044
J.M. ARMSTRONG, N. LATTIMER, S. MONCADA, J.R. VANE, COMPARISON OF THE VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6-OXO-PROSTAGLANDIN F1α WITH THOSE OF PROSTAGLANDIN E2 IN RATS AND RABBITS British Journal of Pharmacology. ,vol. 62, pp. 125- 130 ,(1978) , 10.1111/J.1476-5381.1978.TB07014.X
J.E. Tateson, S. Moncada, J.R. Vane, Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets Prostaglandins. ,vol. 13, pp. 389- 397 ,(1977) , 10.1016/0090-6980(77)90019-3
R. Nizankowski, J. Szczeklik, R.J. Gryglewski, A. Szczeklik, S. Skawinski, P. Gluszko, SUCCESSFUL THERAPY OF ADVANCED ARTERIOSCLEROSIS OBLITERANS WITH PROSTACYCLIN The Lancet. ,vol. 313, pp. 1111- 1114 ,(1979) , 10.1016/S0140-6736(79)91792-6
R.R. Gorman, S. Bunting, O.V. Miller, Modulation of human platelet adenylate cyclase by prostacyclin (PGX). Prostaglandins. ,vol. 13, pp. 377- 388 ,(1977) , 10.1016/0090-6980(77)90018-1
SALVADOR MONCADA, RYSZARD KORBUT, STUART BUNTING, JOHN R. VANE, Prostacyclin is a circulating hormone. Nature. ,vol. 273, pp. 767- 768 ,(1978) , 10.1038/273767A0
A. Dembinska-Kiec, T. Gryglewska, A. Zmuda, R.J. Gryglewski, The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits. Prostaglandins. ,vol. 14, pp. 1025- 1034 ,(1977) , 10.1016/0090-6980(77)90282-9