Zonisamide Treatment Delays Motor Neuron Degeneration and Astrocyte Proliferation in Wobbler Mice
作者： Takehisa Hirayama , Ken Ikeda , Yasushiro Yoshii , Kiyokazu Kawabe
DOI: 10.4021/JNR.V1I4.59
关键词: Neuroprotection 、 Endocrinology 、 Forelimb 、 Motor neuron 、 Medicine 、 Astrocytosis 、 Denervation 、 Anesthesia 、 Atrophy 、 Internal medicine 、 Zonisamide 、 Astrocyte
摘要: Background : Zonisamide (ZNS) had multifunctional effects on several kinds of neurons. Little is known about neuroprotective ZNS motor We aimed to study whether this drug can attenuate neuron degeneration in wobbler mice. Methods Wobbler mice were injected daily two doses (0.2 mg/kg , 2.0 i.p.) or vehicle from aged 3 - 4 weeks at disease onset for more than weeks. Motor function was evaluated by pull-strength and deformity scale the forelimbs. Those symptomatic assessment body weight measured weekly. Neuropathological changes biceps muscle cervical cord analyzed posttreatment. Results treatment (2.0 ) significantly delayed progression forelimb dysfunction compared (P less than 0.01). Gain did not differ statistically between three groups. Higher administration decreased denervation atrophy than 0.01), suppressed loss neurons than 0.01) inhibited astrocyte proliferation Conclusions The present indicated that attenuated astrocytosis mouse. This may have a therapeutic potential disease. doi:10.4021/jnr59w
sci-hub.st 参考文章(24)
Tiziana Mennini, Caterina Bendotti, Excitotoxicity in Amyotrophic Lateral Sclerosis: Selective Vulnerability of Motor Neurons Springer US. pp. 217- 227 ,(2004) , 10.1007/978-1-4419-8959-8_11
Valentina Diana, Arianna Ottolina, Francesca Botti, Elena Fumagalli, Eleonora Calcagno, Massimiliano De Paola, Alfredo Cagnotto, Gloria Invernici, Eugenio Parati, Daniela Curti, Tiziana Mennini, Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake. Experimental Neurology. ,vol. 225, pp. 163- 172 ,(2010) , 10.1016/J.EXPNEUROL.2010.06.008
D. Hantaz-Ambroise, B. Blondet, M. Murawsky, F. Rieger, Abnormal astrocyte differentiation and defective cellular interactions in wobbler mouse spinal cord Journal of Neurocytology. ,vol. 23, pp. 179- 192 ,(1994) , 10.1007/BF01181559
J.S. Dennis, B.A. Citron, Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein Neuroscience. ,vol. 158, pp. 745- 750 ,(2009) , 10.1016/J.NEUROSCIENCE.2008.10.030
Yasuhiko Hashimoto, Katsuya Suemaru, Takahiko Yamamoto, Kenya Kawakami, Hiroaki Araki, Yutaka Gomita, Effect of immobilization stress on anticonvulsant actions and pharmacokinetics of zonisamide in mice Pharmacology Biochemistry and Behavior. ,vol. 68, pp. 7- 12 ,(2001) , 10.1016/S0091-3057(00)00433-0
Ken Ikeda, Yasuo Iwasaki, Masao Kinoshita, Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the wobbler mouse Journal of the Neurological Sciences. ,vol. 160, pp. 9- 15 ,(1998) , 10.1016/S0022-510X(98)00224-X
Andrew J Owen, Sadiq Ijaz, Hiro Miyashita, Tom Wishart, Wendy Howlett, Ashfaq Shuaib, Zonisamide as a neuroprotective agent in an adult gerbil model of global forebrain ischemia: a histological, in vivo microdialysis and behavioral study Brain Research. ,vol. 770, pp. 115- 122 ,(1997) , 10.1016/S0006-8993(97)00789-0
Akitane Mori, Yasuko Noda, Lester Packer, The anticonvulsant zonisamide scavenges free radicals Epilepsy Research. ,vol. 30, pp. 153- 158 ,(1998) , 10.1016/S0920-1211(97)00097-1
H Mitsumoto, K Ikeda, B Klinkosz, J. Cedarbaum, V Wong, R. Lindsay, Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF Science. ,vol. 265, pp. 1107- 1110 ,(1994) , 10.1126/SCIENCE.8066451
Takahiro Hayakawa, Yoshihisa Higuchi, Hiroyuki Nigami, Haruo Hattori, Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect European Journal of Pharmacology. ,vol. 257, pp. 131- 136 ,(1994) , 10.1016/0014-2999(94)90704-8