Excitotoxicity in Amyotrophic Lateral Sclerosis: Selective Vulnerability of Motor Neurons
作者： Tiziana Mennini , Caterina Bendotti
DOI: 10.1007/978-1-4419-8959-8_11
关键词: Medicine 、 Cerebrospinal fluid 、 Transporter 、 In vivo 、 AMPA receptor 、 Glutamate receptor 、 Amyotrophic lateral sclerosis 、 Toxicity 、 Excitotoxicity 、 Neuroscience
摘要: Excessive glutamate concentration is toxic to motor neurons in vitro, thus suggesting the possibil ity that excitotoxicity plays a role neuron degeneration Amyotrophic Lateral Sclerosis. Indeed high levels are found cerebrospinal fluid of about 40% patients, possibly related decrese uptake and EAAT2 transporter. Studies vitro animal models suggest toxicity principally mediated by AMPA receptor subtype, which may enhance calcium influx due changes density and/or editing their GluR2 subunit. Competitive non-competitive antagonists effective on cultured vivo amyotrophic lateral sclerosis. Results from ongoing future clinical trials will give definitive answer relevance AMPA-mediated excitotox icity patients with
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sci-hub.st 参考文章(36)
Davide Trotti, Andreas Rolfs, Niels C. Danbolt, Robert H. Brown, Matthias A. Hediger, SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter Nature Neuroscience. ,vol. 2, pp. 427- 433 ,(1999) , 10.1038/8091
Caterina Bendotti, Massimo Tortarolo, Sachin K. Suchak, Novella Calvaresi, Lucia Carvelli, Antonio Bastone, Massimo Rizzi, Marcus Rattray, Tiziana Mennini, Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels. Journal of Neurochemistry. ,vol. 79, pp. 737- 746 ,(2008) , 10.1046/J.1471-4159.2001.00572.X
Sean G. Carriedo, Hong Z. Yin, John H. Weiss, Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated Injury In Vitro The Journal of Neuroscience. ,vol. 16, pp. 4069- 4079 ,(1996) , 10.1523/JNEUROSCI.16-13-04069.1996
Wim Vandenberghe, Eva C. Ihle, Doris K. Patneau, Wim Robberecht, James R. Brorson, AMPA Receptor Current Density, Not Desensitization, Predicts Selective Motoneuron Vulnerability The Journal of Neuroscience. ,vol. 20, pp. 7158- 7166 ,(2000) , 10.1523/JNEUROSCI.20-19-07158.2000
Jeffrey D. Rothstein, Lee J. Martin, Ralph W. Kuncl, Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis The New England Journal of Medicine. ,vol. 326, pp. 1464- 1468 ,(1992) , 10.1056/NEJM199205283262204
Philip Van Damme, Maarten Leyssen, Geert Callewaert, Wim Robberecht, Ludo Van Den Bosch, The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis. Neuroscience Letters. ,vol. 343, pp. 81- 84 ,(2003) , 10.1016/S0304-3940(03)00314-8
T Mennini, A Bastone, D Crespi, D Comoletti, C Manzoni, Spinal cord GLT-1 glutamate transporter and blood glutamic acid alterations in motor neuron degeneration (Mnd) mice Journal of the Neurological Sciences. ,vol. 157, pp. 31- 36 ,(1998) , 10.1016/S0022-510X(98)00072-0
Odile Spreux-Varoquaux, Gilbert Bensimon, Lucette Lacomblez, François Salachas, Pierre François Pradat, Nadine Le Forestier, Abdellatif Marouan, Michel Dib, Vincent Meininger, Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients. Journal of the Neurological Sciences. ,vol. 193, pp. 73- 78 ,(2002) , 10.1016/S0022-510X(01)00661-X
D Comoletti, V Muzio, A Capobianco, T Ravizza, T Mennini, Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures. Journal of the Neurological Sciences. ,vol. 192, pp. 61- 69 ,(2001) , 10.1016/S0022-510X(01)00607-4
P. L. McGeer, E. G. McGeer, Inflammatory processes in amyotrophic lateral sclerosis. Muscle & Nerve. ,vol. 26, pp. 459- 470 ,(2002) , 10.1002/MUS.10191