Inflammatory processes in amyotrophic lateral sclerosis.

摘要: Neuroinflammation is a characteristic of pathologically affected tissue in several neurodegenerative disorders. These changes can be observed the brainstem and spinal cord amyotrophic lateral sclerosis (ALS) cases mouse models disease. They include an accumulation large numbers activated microglia astrocytes, as well small T cells, mostly adhering to postcapillary venules. Accompanying biochemical alterations appearance numerous molecules free-radical attack, occurrence proteins associated with activation complement cascade, sharp upregulation enzyme cyclooxygenase 2 (COX-2). Anti-inflammatory agents may have role play treating ALS. COX-2 particularly attractive target because its marked increase ALS cord.