Somatic damage to the X chromosome of the nematode Caenorhabditis elegans induced by gamma radiation

作者: Philip S. Hartman , Robert K. Herman

DOI: 10.1007/BF00384393

关键词: EmbryoMutationSomatic cellX chromosomeGeneticsMolecular biologyLarvaRadiosensitivityBiologyCellTransformation (genetics)

摘要: Wild-type male embryos and young larvae of the nematode Caenorhabditis elegans were more sensitive than wild-type hermaphrodites to inactivation by gamma rays; males have one X chromosome per cell (XO), whereas two (XX). Furthermore, after transformation into fertile a her-1 mutation, XO animals radiosensitive XX animals; transformed tra-1 mutation did not show increased radiosensitivity. It is concluded that are because they rather two, predominant mode involves damage single chromosome. No sex-specific differences in survival observed UV irradiation.

参考文章(19)
R. S. Edgar, T. : Leighton, W. F. Loomis, The genetics of development in the nematode Caenorhabditis elegans. The genetics of development in the nematode Caenorhabditis elegans.. pp. 213- 235 ,(1980)
Jonathan Hodgkin, MORE SEX-DETERMINATION MUTANTS OF CAENORHABDITIS ELEGANS Genetics. ,vol. 96, pp. 649- 664 ,(1980) , 10.1093/GENETICS/96.3.649
S Brenner, THE GENETICS OF CAENORHABDITIS ELEGANS Genetics. ,vol. 77, pp. 71- 94 ,(1974) , 10.1093/GENETICS/77.1.71
Sydney Brenner, Jonathan Hodgkin, H. Robert Horvitz, Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS. Genetics. ,vol. 91, pp. 67- 94 ,(1979) , 10.1093/GENETICS/91.1.67
N. ISHII, K. SUZUKI, The Killing Effects of Ultraviolet Light and X-rays on Free-living Nematode, Rhabditidae tokai Journal of Radiation Research. ,vol. 21, pp. 137- 147 ,(1980) , 10.1269/JRR.21.137
J.E. Sulston, D.G. Albertson, J.N. Thomson, The Caenorhabditis elegans male: postembryonic development of nongonadal structures. Developmental Biology. ,vol. 78, pp. 542- 576 ,(1980) , 10.1016/0012-1606(80)90352-8
J.E. Sulston, H.R. Horvitz, Post-embryonic cell lineages of the nematode, Caenorhabditis elegans Developmental Biology. ,vol. 56, pp. 110- 156 ,(1977) , 10.1016/0012-1606(77)90158-0