Phosphofluoridates: Biological Activity and Biodegradation

作者: Joseph J. DeFrank , William E. White

DOI: 10.1007/10721878_10

关键词: Biological activityBiodegradationEnzymeChemistryCatalysisPhosphorusOrganic chemistry

摘要: The combination of phosphorus and fluorine has resulted in a variety compounds that are unique their physical chemical properties as well being some the most toxic materials produced by man. A review chemistry enzymatic basis for toxicology these is presented. Catalytic enzymes use substrates potential applications also reviewed.

参考文章(121)
Matthew M. Benning, Jane M. Kuo, Frank M. Raushel, Hazel M. Holden, Three-dimensional structure of phosphotriesterase: an enzyme capable of detoxifying organophosphate nerve agents. Biochemistry. ,vol. 33, pp. 15001- 15007 ,(1994) , 10.1021/BI00254A008
Valerie Daggett, Stefan Schroeder, Peter Kollman, Catalytic pathway of serine proteases: classical and quantum mechanical calculations Journal of the American Chemical Society. ,vol. 113, pp. 8926- 8935 ,(1991) , 10.1021/JA00023A047
Yacov Ashani, Nathan Rothschild, Yoffi Segall, Dan Levanon, Lily Raveh, Prophylaxis against organophsphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice Life Sciences. ,vol. 49, pp. 367- 374 ,(1991) , 10.1016/0024-3205(91)90444-G
F. C. G. Hoskin, G. S. Trick, STEREOSPECIFICITY IN THE ENZYMATIC HYDROLYSIS OF TABUN AND ACETYL-β-METHYLCHOLINE CHLORIDE Canadian Journal of Biochemistry and Physiology. ,vol. 33, pp. 963- 969 ,(1955) , 10.1139/O55-116
Wayne G. Landis, Donna M. Haley, Mark V. Haley, Dennis W. Johnson, H. Dupont Durst, Russell E. Savage, Discovery of multiple organofluorophosphate hydrolyzing activities in the protozoan Tetrahymena thermophila. Journal of Applied Toxicology. ,vol. 7, pp. 35- 41 ,(1987) , 10.1002/JAT.2550070107
F. C. G. Hoskin, THE ENZYMATIC HYDROLYSIS PRODUCTS OF SARIN Biochemistry and Cell Biology. ,vol. 34, pp. 75- 79 ,(1956) , 10.1139/Y56-009
A. Mulchandani, S. Pan, W. Chen, Fiber‐Optic Enzyme Biosensor for Direct Determination of Organophosphate Nerve Agents Biotechnology Progress. ,vol. 15, pp. 130- 134 ,(1999) , 10.1021/BP980111Q
WAYNE G. LANDIS, MARK V. HALEY, DENNIS W. JOHNSON, Kinetics of the DFPase activity in Tetrahymena thermophila. Journal of Eukaryotic Microbiology. ,vol. 33, pp. 216- 218 ,(1986) , 10.1111/J.1550-7408.1986.TB05593.X