CRF07_BC Strain Dominates the HIV-1 Epidemic in Injection Drug Users in Liangshan Prefecture of Sichuan, China

摘要: Abstract The Liangshan prefecture in Sichuan province is an area China severely affected by the HIV epidemic, with intravenous drug use (IDU) as main risk factor. No reports on subtypes prevalent IDUs could be found. In this study, we have characterized genotypes of HIV-1 IDU population and further determined phylogenetic relationship CRF07_BC strains to sequences from other regions China, including Xinjiang Yunnan provinces, explore pattern possible diffusion pathway these regions. HIV-1-seropositive drug-naive identified prefecture, were enrolled 2009. Full-length gag pol genes amplified reverse transcription nested PCR then sequenced. All subtyped. Phylogenetic trees constructed using neighbor-joining maximum likelihood methods. Divergence times estimated a Bayesian molecular cl...