Selenium in forage crops and cancer mortality in U.S. counties.

作者: Larry C. Clark , Kenneth P. Cantor , W. H. Allaway

DOI: 10.1080/00039896.1991.9937427

关键词: Regression analysisDemographyCervixEcological studyEsophagusCancerRectumMedicineEpidemiologySelenium

摘要: The potential protective effect of selenium status on the risk developing cancer has been examined in animal and epidemiologic studies. This ecological study investigated association between U.S. county forage site- sex-specific mortality rates (1950-1969) using weighted least squares regression. Consistent, significant (p less than .01) inverse associations were observed for cancers lung, rectum, bladder, esophagus, cervix a model limited to rural counties breast, corpus uteri all counties. No consistent positive models. remarkable degree consistency strengthens likelihood causal relationship low an increased mortality.

参考文章(15)
National Cancer Institute (U.S.). Epidemiology Branch, Atlas of cancer mortality for U.S. counties, 1950-1969 U.S. Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health. ,(1975)
Anthony J. Barr, SAS user's guide SAS Institute Inc.. ,(1979)
R. J. Shamberger, D. V. Frost, Possible protective effect of selenium against human cancer. Canadian Medical Association Journal. ,vol. 100, pp. 682- 682 ,(1969)
Larry C. Clark, Gerald F. Combs, Selenium compounds and the prevention of cancer: research needs and public health implications. Journal of Nutrition. ,vol. 116, pp. 170- 173 ,(1986) , 10.1093/JN/116.1.170
FRANS J. KOK, ANTHONY M. DE BRUIJN, ALBERT HOFMAN, RENE VERMEEREN, HANS A. VALKENBURG, IS SERUM SELENIUM A RISK FACTOR FOR CANCER IN MEN ONLY American Journal of Epidemiology. ,vol. 125, pp. 12- 16 ,(1987) , 10.1093/OXFORDJOURNALS.AJE.A114493
G.N. Schrauzer, D.A. White, C.J. Schneider, Cancer mortality correlation studies-III: Statistical associations with dietary selenium intakes Bioinorganic Chemistry. ,vol. 7, pp. 23- 34 ,(1977) , 10.1016/S0006-3061(00)80126-X
Joseph F. Fraumeni, William J. Blot, Geographic variation in esophageal cancer mortality in the United States Journal of Chronic Diseases. ,vol. 30, pp. 759- 767 ,(1977) , 10.1016/0021-9681(77)90004-2
J. Steven Morris, Meir J. STAMPFER, Walter Willett, Dietary selenium in humans toenails as an indicator Biological Trace Element Research. ,vol. 5, pp. 529- 537 ,(1983) , 10.1007/BF02988944
U. M. Cowgill, The distribution of selenium and cancer mortality in the continental United States Biological Trace Element Research. ,vol. 5, pp. 345- 361 ,(1983) , 10.1007/BF02987219