Preparation and characterization of atenolol-loaded cellulose acetate butyrate-poly(vinyl pyrrolidone) blend microspheres: in vitro release studies
作者： V. Ramesh Babu , K. Mallikarjuna Reddy , M. Sairam , M. C. S. Subha , N. N. Mallikarjuna
DOI: 10.1163/156855507780378276
关键词: Drug carrier 、 Cellulose acetate 、 Differential scanning calorimetry 、 Polymer blend 、 Vinyl alcohol 、 Controlled release 、 Microparticle 、 Polymer chemistry 、 Particle size 、 Materials science 、 Nuclear chemistry
摘要: Cellulose acetate butyrate-poly(vinyl pyrrolidone) (CAB-PVP) blend microspheres were prepared using the solvent evaporation technique poly(vinyl alcohol) as an emulsifying agent. Atenolol (ATNL), antihypertensive drug, was successfully loaded into these microspheres. Effect of experimental variables such CAB/PVP ratio on ATNL encapsulation efficiency, release rate, size and morphology has been investigated. ATNL-loaded analyzed differential scanning calorimetry to investigate crystalline nature after encapsulation. DSC results indicated a non-uniform dispersion in CAB-PVP matrix. Scanning electron micrographs formation spherical Mean particle microspheres, measured by laser light scattering technique, ranged between 100 120 μm. An about 80% achieved. In vitro dissolution experiments performed pH 7.4 buffer medium controlled re...
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G. Habermehl, ReviewPure appl. Chem: Rinehart, K. L., et al. Marine natural products as sources of antiviral, antimicrobial, and antineoplastic Agents. 53, 795 (1981). (K. L. Rinehart, University of Illinois, Urbana, IL 61801, U.S.A.) Toxicon. ,vol. 21, pp. 732- 733 ,(1983) , 10.1016/0041-0101(83)90286-6
Alvaro Federico Jimenez-Kairuz, Juan Manuel Llabot, Daniel Alberto Allemandi, Ruben Hilario Manzo, Swellable drug-polyelectrolyte matrices (SDPM): Characterization and delivery properties International Journal of Pharmaceutics. ,vol. 288, pp. 87- 99 ,(2005) , 10.1016/J.IJPHARM.2004.09.014
Khawla Abu-Izza, Laura Tambrallo, D. Robert Lu, In Vivo Evaluation of Zidovudine (AZT)-Loaded Ethylcellulose Microspheres After Oral Administration in Beagle Dogs Journal of Pharmaceutical Sciences. ,vol. 86, pp. 554- 559 ,(1997) , 10.1021/JS960461B
Paresh S. Dalal, Milind M. Narurkar, In vitro and in vivo evaluation of sustained release suspensions of ibuprofen International Journal of Pharmaceutics. ,vol. 73, pp. 157- 162 ,(1991) , 10.1016/0378-5173(91)90039-Q
Richard W. Korsmeyer, Nikolaos A. Peppas, Effect of the morphology of hydrophilic polymeric matrices on the diffusion and release of water soluble drugs Journal of Membrane Science. ,vol. 9, pp. 211- 227 ,(1981) , 10.1016/S0376-7388(00)80265-3
H. Abdel Monem Sayed, J. C. Price, Tablet Properties and Dissolution Characteristics of Compressed Cellulose Acetate Butyrate Microcapsules Containing Succinyl Sulfathiazole Drug Development and Industrial Pharmacy. ,vol. 12, pp. 577- 587 ,(1986) , 10.3109/03639048609048030
D.T. O'Hagan, K. Palin, S.S. Davis, P. Artursson, I. Sjöholm, Microparticles as potentially orally active immunological adjuvants. Vaccine. ,vol. 7, pp. 421- 424 ,(1989) , 10.1016/0264-410X(89)90156-4
P.Rama Rao, Prakash V. Diwan, Permeability studies of cellulose acetate free films for transdermal use: Influence of plasticizers Pharmaceutica Acta Helvetiae. ,vol. 72, pp. 47- 51 ,(1997) , 10.1016/S0031-6865(96)00060-X
S SVEINSSON, T KRISTMUNDSDOTTIR, K INGVARSDOTTIR, The effect of tableting on the release characteristics of naproxen and ibuprofen microcapsules International Journal of Pharmaceutics. ,vol. 92, pp. 29- 34 ,(1993) , 10.1016/0378-5173(93)90260-M
ROLAND BODMEIER, HUAGANG CHEN, Preparation of biodegradable poly(+/-)lactide microparticles using a spray-drying technique. Journal of Pharmacy and Pharmacology. ,vol. 40, pp. 754- 757 ,(2011) , 10.1111/J.2042-7158.1988.TB05166.X