Fibrocytes can be reprogrammed to promote tissue remodeling capacity of dermal fibroblasts

摘要: Fibroblasts play a pivotal role in wound healing process participating both tissue fibrosis and remodeling. However, it remains unclear which factors activate such diversity of fibroblast responses how this decision-making is made. Previous reports have demonstrated that milieu stimulates the transformation circulating precursor cells into fibrocytes. These pro-fibrogenic promote collagen production by resident fibroblasts. Conversely, recruited with anti-fibrogenic profile can compete fibrocytes not been identified. This report describes novel transdifferentiation induced changing culture conditions. The reprogrammed markedly increased cell proliferation MMP-1 expression dermal up-regulation was directly related to number followed transformation. In vitro vivo results confirmed TGF-β deprivation plays an important fibrocyte differentiation pathway. Our findings demonstrate that, commitment, possible exponentially stimulate remodeling capacity will open new research approaches understand local environment only skin, but also several other fibrocyte-associated diseases as lung fibrosis, asthma, liver cirrhosis, chronic pancreatitis, atherosclerosis.