Detection of Alveolar Fibrocytes in Idiopathic Pulmonary Fibrosis and Systemic Sclerosis
作者： Raphael Borie , Christophe Quesnel , Sophie Phin , Marie-Pierre Debray , Joelle Marchal-Somme
DOI: 10.1371/JOURNAL.PONE.0053736
关键词:
摘要: Background: Fibrocytes are circulating precursors for fibroblasts. Blood fibrocytes increased in patients with idiopathic pulmonary fibrosis (IPF). The aim of this study was to determine whether alveolar detected broncho-alveolar lavage (BAL), identify their prognostic value, and potential association culture fibroblasts from BAL. Methods: We quantified BAL 26 IPF, 9 Systemic Sclerosis(SSc)-interstitial lung disease (ILD), 11 controls. cells were cultured isolate fibroblasts. Results:Fibrocytes 14/26 IPF (54%) 5/9 SSc (55%), never median 2.5% [0.4–19.7] 3.0% [2.7–3.7] SSc-ILD respectively. In patients, the number correlated macrophages associated a less severe but not better outcome. Fibroblasts 12/26 (46%), (65%) detection did predict positive fibroblasts. Conclusion:Fibrocytes fluid about half SSc-ILD. Their associate capacity grow fluid.
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