The expression of TTF1, CDX2 and ISL1 in 74 poorly differentiated neuroendocrine carcinomas.
作者： Hwajeong Lee , Zhiyan Fu , Brandon H Koo , Christine E Sheehan , Gloria Q Young
DOI: 10.1016/J.ANNDIAGPATH.2018.09.005
关键词: ISL1 、 Poorly differentiated 、 Pathology 、 CDX2 、 Immunohistochemistry 、 Cell 、 Staining 、 Large cell 、 Lung 、 Medicine
摘要: Abstract Background The expression profile of immunohistochemical markers origin in poorly differentiated neuroendocrine carcinoma (PDNEC) is not well studied. Materials and methods Seventy-four PDNECs from gastroenteropancreatic (GEP) organs the lung, including 48 large cell NEC (LCNEC) 26 small carcinomas (SmCC), were subject to staining for CDX2, TTF1 ISL1. intensity (1 3) percentage positive tumor cells [0 (negative), 1 ( Results In 38 GEP 36 lung PDNECs, ISL1 was observed 71% (aTS 2.8), 16% 0.4), 63% 1.9), 22% 0.6), 72% 2.9) 92% 3.8), respectively. showed a higher aTS CDX2 lower ISL1, compared that (Student's t-test, p Conclusions demonstrate potential utility suggesting primary site PDNEC. addition, may be useful supporting diagnosis LCNEC cases with overlapping or borderline morphology. Utility as an adjunctive diagnostic marker SmCC remains
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sci-hub.se 参考文章(30)
Morena Fasano, Carminia Maria Della Corte, Federica Papaccio, Fortunato Ciardiello, Floriana Morgillo, Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy Journal of Thoracic Oncology. ,vol. 10, pp. 1133- 1141 ,(2015) , 10.1097/JTO.0000000000000589
Christophe Couderc, Gilles Poncet, Karine Villaume, Martine Blanc, Nicolas Gadot, Thomas Walter, Florian Lepinasse, Valérie Hervieu, Martine Cordier-Bussat, Jean-Yves Scoazec, Colette Roche, Targeting the PI3K/mTOR pathway in murine endocrine cell lines: in vitro and in vivo effects on tumor cell growth. American Journal of Pathology. ,vol. 178, pp. 336- 344 ,(2011) , 10.1016/J.AJPATH.2010.11.023
Muhammad F Bari, Helen Brown, Andrew G Nicholson, Keith M Kerr, John R Gosney, William A Wallace, Irshad Soomro, Salli Muller, Danielle Peat, Jonathan D Moore, Lesley A Ward, Maxim B Freidin, Eric Lim, Manu Vatish, David R J Snead, BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas Histopathology. ,vol. 64, pp. 547- 556 ,(2014) , 10.1111/HIS.12278
Julien Bollard, Christophe Couderc, Martine Blanc, Gilles Poncet, Florian Lepinasse, Valérie Hervieu, Géraldine Gouysse, Carole Ferraro-Peyret, Noura Benslama, Thomas Walter, Jean-Yves Scoazec, Colette Roche, Antitumor effect of everolimus in preclinical models of high-grade gastroenteropancreatic neuroendocrine carcinomas. Neuroendocrinology. ,vol. 97, pp. 331- 340 ,(2013) , 10.1159/000347063
Robert W. Werling, Hadi Yaziji, Carlos E. Bacchi, Allen M. Gown, CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. The American Journal of Surgical Pathology. ,vol. 27, pp. 303- 310 ,(2003) , 10.1097/00000478-200303000-00003
Jau-Yu Liau, Jia-Huei Tsai, Yung-Ming Jeng, Kuan-Ting Kuo, Hsin-Yi Huang, Cher-Wei Liang, Ching-Yao Yang, The Diagnostic Utility of PAX8 for Neuroendocrine Tumors: An Immunohistochemical Reappraisal. Applied Immunohistochemistry & Molecular Morphology. ,vol. 24, pp. 57- 63 ,(2016) , 10.1097/PAI.0000000000000149
Yasushi Yatabe, Takaomi Koga, Tetsuya Mitsudomi, Takashi Takahashi, CK20 expression, CDX2 expression, K-ras mutation, and goblet cell morphology in a subset of lung adenocarcinomas. The Journal of Pathology. ,vol. 203, pp. 645- 652 ,(2004) , 10.1002/PATH.1566
AKIRA IYODA, WILLIAM D. TRAVIS, INDERPAL S. SARKARIA, SHI-XU JIANG, HIDEKI AMANO, YUICHI SATO, MAKOTO SAEGUSA, VALERIE W. RUSCH, YUKITOSHI SATOH, Expression profiling and identification of potential molecular targets for therapy in pulmonary large-cell neuroendocrine carcinoma. Experimental and Therapeutic Medicine. ,vol. 2, pp. 1041- 1045 ,(2011) , 10.3892/ETM.2011.343
Xiaoqi Lin, Reda S. Saad, Todd M. Luckasevic, Jan F. Silverman, Yulin Liu, Diagnostic value of CDX-2 and TTF-1 expressions in separating metastatic neuroendocrine neoplasms of unknown origin. Applied Immunohistochemistry & Molecular Morphology. ,vol. 15, pp. 407- 414 ,(2007) , 10.1097/01.PAI.0000210416.53493.0F
Hind Nassar, Jorge Albores-Saavedra, David S Klimstra, High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases. The American Journal of Surgical Pathology. ,vol. 29, pp. 588- 594 ,(2005) , 10.1097/01.PAS.0000157974.05397.4F