Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori.

摘要: Background Ginger root (Zingiber officinale) has been used traditionally for the treatment of gastrointestinal ailments such as motion sickness, dyspepsia and hyperemesis gravidarum, is also reported to have chemopreventative activity in animal models. The gingerols are a group structurally related polyphenolic compounds isolated from ginger known be active constituents. Since Helicobacter pylori (HP) primary etiological agent associated with dyspepsia, peptic ulcer disease development gastric colon cancer, anti-HP effects its constituents were tested vitro. Materials methods A methanol extract dried powdered rhizome, fractions constituents, 6-,8-,10-gingerol 6-shogoal, against 19 strains HP, including 5 CagA+ strains. Results rhizome inhibited growth all vitro minimum inhibitory concentration range 6.25-50 micrograms/ml. One fraction crude extract, containing gingerols, was HP an MIC 0.78 12.5 micrograms/ml significant Conclusion These data demonstrate that extracts inhibit H. this may contribute effects.