Prognostic variables in patients with hepatic metastases from colorectal cancer. Importance of medical assessment of liver involvement.

摘要: Variation in response rates to chemotherapy and survival patients with hepatic metastases from colorectal carcinoma may be due patient selection factors. The prognostic importance of 13 factors were analyzed 112 only metastases, who eligible for artery infusional chemotherapy. When individually analyzed, six found significantly (less than 0.001) affect survival: the percentage tumor involvement liver, assessed medically or surgically; initial serum albumin lactic dehydrogenase; Karnofsky performance status; weight loss. Patients less equal 30% liver had a median 24 months versus 10 if they greater involvement. There was highly significant agreement between medical surgical assessment (P = 0.0001). variables affecting studied together by multivariable analyses, most important factor accomplished evaluation radionuclide scan CTT scans. next two model ability obtain presence absence Only one helped predict chemotherapy, type perfusion seen on 99Technetium-macroaggregated (MAA) arterial flow scan. Forty-five percent good partial while 13% poor 0.006). We recommend that future studies, dealing have are infusion, document stratify following factors: involvement, loss, MAA