Angiotensin-Forming Enzyme in Brain Tissue
作者： D. Ganten , J. L. Minnich , P. Grenger , K. Hayduk , H. M. Brecht
DOI: 10.1126/SCIENCE.173.3991.64
关键词: Enzyme inducer 、 Renin–angiotensin system 、 Endocrinology 、 Angiotensinogenase 、 Internal medicine 、 Substrate (chemistry) 、 Chemistry 、 Enzyme assay 、 Plasma renin activity 、 Aldosterone 、 Kidney
摘要: A renin-like enzyme is present in brain tissue and independent of kidney plasma renin. In the presence homologous substrate it forms angiotensin. Administration aldosterone significantly decreases this angiotensinforming activity, while administration progesterone markedly enhances it.
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harvard.edu参考文章(17)
Joan Summy-Long, Walter B. Severs, John D. Connor, James S. Taylor, A central effect of angiotensin: release of pituitary pressor material. Journal of Pharmacology and Experimental Therapeutics. ,vol. 174, pp. 27- 34 ,(1970)
M. Roth, A. F. Weitzman, Yvonne Piquilloud, Converting enzyme content of different tissues of the rat Experientia. ,vol. 25, pp. 1247- 1247 ,(1969) , 10.1007/BF01897474
M.W Brightman, I Klatzo, Y Olsson, T.S Reese, The blood-brain barrier to proteins under normal and pathological conditions Journal of the Neurological Sciences. ,vol. 10, pp. 215- 239 ,(1970) , 10.1016/0022-510X(70)90151-6
Dorothy E. Woolley, Paola S. Timiras, WATER AND ELECTROLYTE ALTERATIONS IN PLASMA, BRAIN AND LIVER OF RATS AFTER CASTRATION AND SEX HORMONE ADMINISTRATION. European Journal of Endocrinology. ,vol. 46, pp. 12- 24 ,(1964) , 10.1530/ACTA.0.0460012
DETLEV GANTEN, KARL HAYDUK, HANS MICHAEL BRECHT, ROGER BOUCHER, JACQUES GENEST, Evidence of Renin Release or Production in Splanchnic Territory Nature. ,vol. 226, pp. 551- 552 ,(1970) , 10.1038/226551A0
H. J. SCHÜMANN, K. STARKE, U. WERNER, R. HELLERFORTH, The influence of angiotensin on the uptake of noradrenaline by the isolated heart of the rabbit Journal of Pharmacy and Pharmacology. ,vol. 22, pp. 441- 446 ,(2011) , 10.1111/J.2042-7158.1970.TB08559.X
Harold Koenig, Dorothy Gaines, Thomas McDonald, Rosalind Gray, James Scott, STUDIES OF BRAIN LYSOSOMES. I. SUBCELLULAR DISTRIBUTION OF FIVE ACID HYDROLASES, SUCCINATE DEHYDROGENASE AND GANGLIOSIDES IN RAT BRAIN. Journal of Neurochemistry. ,vol. 11, pp. 729- 743 ,(1964) , 10.1111/J.1471-4159.1964.TB06118.X
A. N. Epstein, J. T. Fitzsimons, Barbara J. Rolls, Drinking induced by injection of angiotensin into the brain of the rat The Journal of Physiology. ,vol. 210, pp. 457- 474 ,(1970) , 10.1113/JPHYSIOL.1970.SP009220
R. Boucher, J. Ménard, J. Genest, A micromethod for measurement of renin in the plasma and kidney of rats. Canadian Journal of Physiology and Pharmacology. ,vol. 45, pp. 881- 890 ,(1967) , 10.1139/Y67-103
E. M. SYMONDS, MARGARET A. STANLEY, S. L. SKINNER, Production of renin by in vitro cultures of human chorion and uterine muscle. Nature. ,vol. 217, pp. 1152- 1153 ,(1968) , 10.1038/2171152A0