Central Mediation of Water and Sodium Intake: A Dual Role for Angiotensin?

摘要: Available data establish that angiotensin II (as well as its precursor I, or renin) can directly indirectly influence the neural systems mediating water ingestion in mammal. All of these compounds elicit drinking following either intravascular infusion injection into certain brain regions (Epstein, Fitzsimons and Simons, 1970; 1969). In fact, is most potent experimentally useful dipsogen yet discovered, indicated by threshold latency data, reproducibility action effectiveness across species (Andersson Westbye, Epstein, 1972; Fitzsimons, Setler, 1971). However, conceptual difficulties arise if one asks why this should be so, whether reflect meaningful physiological mechanisms. For example, a pressor hormone formed from kidney-based renin response to hypovolaemia hypotension (Leenen Stricker, volume; Meyer, Peskar, Tauchmann Hertting, 1971; Brown, Davies, Lever, Robertson, Verniory, 1966; Peart, 1969; Pitcock, Hartroft, Newmark, 1959; Vander, 1967) Water not an adaptive such challenges, since outcome behaviour will relieve imbalance which triggered it because ingested distributed intra-cellularly.