Complement related kidney diseases: Recurrence after transplantation

摘要: The recurrence of renal disease after transplantation is becoming one the main causes graft loss kidney transplantation. This principally concerns some original diseases as atypical hemolytic uremic syndrome (HUS), membranoproliferative glomerulonephritis (MPGN), in particular MPGN now called C3 glomerulopathy. Both this groups are characterized by congenital (genetic) or acquired (auto-antibodies) modifications alternative pathway complement. These abnormalities often remain because they constitutional and poorly influenced immunosuppression. fact justifies high rate these diseases. Early diagnosis essential for an optimal therapeutically approach, whenever possible. Patients affected end stage due to glomerulopathies HUS, may be transplanted with extreme caution. Living donor donation from relatives not recommended members same family gene mutation. Different approaches have been attempted either prevention treatment. most promising approach represented complement inhibitors. Eculizumab, a monoclonal antibody against C5 convertase drug, even if date known how long therapy should continued which best dosing. facts face costs Eculizumab resistant patients described. They could benefit inhibitor, but class drugs object randomized controlled trials.