Regulation of Bone Marrow Myeloblast Proliferation in Chronic Myeloid Leukemia

摘要: The in vitro [3H]thymidine-labeling index of bone marrow myeloblasts and myelocytes was determined for 9 hematologically normal individuals 20 Ph1-positive chronic myeloid leukemia (CML) patients the phase their disease. mean labeling from CML when white blood cell (WBC) count lower than 20,000/cu mm (42.4%) not significantly different that (49.9). This found to be ( p < 0.05) decreased an average 20.9% WBC higher 40,000/cu mm. influenced by level WBC. The data presented indicate such variations leukemic represent changes proliferative activity related WBC. It is concluded proliferation sensitive, a certain degree at least, size population body or subclass it.