Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species
作者： Marina D. Kraaij , Nigel D. L. Savage , Sandra W. van der Kooij , Karin Koekkoek , Jun Wang
关键词: NADPH oxidase 、 Reactive oxygen species 、 Immune system 、 Autoimmunity 、 Inflammation 、 Phagocyte 、 Chronic granulomatous disease 、 Oxidase test 、 Immunology 、 Biology
摘要: The phagocyte NAPDH–oxidase complex consists of several oxidase (phox) proteins, generating reactive oxygen species (ROS) upon activation. ROS are involved in the defense against microorganisms and also immune regulation. Defective formation leads to chronic granulomatous disease (CGD) with increased incidence autoimmunity disturbed resolution inflammation. Because regulatory T cells (Tregs) suppress autoimmune T-cell responses crucial down-regulating responses, we hypothesized that deficiency may lead decreased Treg induction. Previously, showed p47phox-mutated mice, reconstitution macrophages (Mph) ROS-producing capacity was sufficient protect mice from arthritis. Now, present evidence Mph-derived induce Tregs. In vitro, Mph ROS-dependently Treg, using an NADPH-oxidase inhibitor. This finding confirmed genetically: rat or human CGD mutated p47phox gp91phox displayed hampered induction suppression. However, basal numbers these subjects were comparable those controls, indicating a role for peripheral Induction allogeneic delayed-type hypersensitivity importance vivo. We conclude NAPDH activity is important Tregs regulate cell-mediated
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