The sciatic nerve injury model in pre-clinical research

作者: Stefano Geuna

DOI: 10.1016/J.JNEUMETH.2015.01.021

关键词: Sciatic nerve injuryExperimental modelSciatic nerveSciatic NeuropathyNerve repairPeripheral nerveNeuroscienceRegeneration (biology)MedicineClinical research

摘要: In the pre-clinical view, study of peripheral nerve repair and regeneration still needs to be carried out in animal models due structural complexity this organ which can only partly simulated vitro. The far most used experimental model is based on injury sciatic nerve, largest trunk mammals. paper, potential application research critically reviewed. This paper aimed at helping researchers properly employing vivo for as well interpreting results a clinical translation perspective.

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