Delayed access of low body weight-selected chicks to food at hatch is associated with up-regulated pancreatic glucagon and glucose transporter gene expression
作者： Grace A. Parker , Lindsay H. Sumners , Xiaoling Zhao , Christa F. Honaker , Paul B. Siegel
DOI: 10.1016/J.CBPA.2015.08.004
关键词: Glucose transporter 、 Internal medicine 、 GLUT2 、 Pancreas 、 Endocrinology 、 PDX1 、 Preproinsulin 、 Gene expression 、 Endocrine system 、 Biology 、 Glucagon
摘要: Chickens selected for low (LWS) and high (HWS) juvenile body weight (BW) 55 generations differ in BW by 10-fold at selection age. High (HWR) (LWR) weight-relaxed lines have been random-bred since the 46th generation. Our objective was to evaluate developmental nutritional regulation of pancreatic mRNA abundance duodenal homeobox 1 (PDX1), preproinsulin (PPI), preproglucagon (PPG), glucose transporter 2 (GLUT2). At day hatch (DOH) days 1, 3, 7, 15 (D1, 7 15, respectively), pancreas collected real time PCR performed Experiment 1. In 2, HWS LWS were fed or delayed access food 72 h post-hatch, D15. There an interaction line age GLUT2 (P=0.001), PPI (P<0.0001), PPG (P=0.034), PDX1 (P<0.0001). Expression greater chicks from LWR than HWR HWS. nutrition on (P<0.0001) (P=0.001) mRNA, where expression similar among that but when food. Thus, first two weeks is important maturation endocrine function. Long-term associated with differences development, delaying may persisting effects regulatory
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